Aims and Scope
Recent Articles
Serum Vitamin D Levels at Different Stages of Acne Vulgaris Patients Treated with Isotretinoin: A Prospective Study
Mohammed Al-Dhubaibi, Ghadah Alhetheli, Adel Alsenaid, Ahmed Abd ElneamBackground:
Acne vulgaris is a common chronic inflammatory skin disorder of pilosebaceous units. Isotretinoin (13-cis retinoic acid) is the most effective multifunctional treatment for moderate-to-severe and nodulocystic acne. Vitamin D plays a role in the immune system, and its deficiency might contribute to the pathogenesis of acne.
Objective:
To investigate whether isotretinoin improves serum 25-hydroxyvitamin D levels in acne vulgaris patients.
Methods:
This prospective cohort study included 68 patients with acne vulgaris. Lipid profiles, liver function tests, and serum 25-hydroxyvitamin D [25 (OH) D] levels were measured at baseline and three months after starting isotretinoin treatment.
Results:
There was a significant increase in serum vitamin D levels three months after starting isotretinoin treatment in mild acne patients (P=0.0003).
Conclusion:
Vitamin D levels are altered in acne vulgaris. Isotretinoin therapy is associated with an increase in vitamin D levels, which was statistically significant in mild acne patients. Considering the role of vitamin D in acne, effective treatment with isotretinoin might highlight vitamin D as a possible target for acne therapy or as a biomarker for disease activity and remission.
February 23, 2021
Editor's Choice
Pyoderma Gangrenosum of the Face: A Rare Presentation and a Rapid Resolution
Julia Shah, Lorie Gottwald, Ashley Sheskey, Craig Burkhart
Background:
Pyoderma Gangrenosum (PG) is a disorder of neutrophil chemotaxis that often affects the lower extremities of patients with concurrent autoimmune disorders.
Result and Discussion:
Resolution of lesions typically requires a minimum of six weeks of treatment with systemic steroids. We present a unique case of multifocal PG involving the hand and face that healed after ten days of treatment with oral prednisone.
June 14, 2018
Other Post
- May 31, 2018
Topical 1% Propranolol in Liposomal Gel: A New Adjuvant Tool for Chronic Leprosy Ulcers
April 30, 2018
0.1MG/ML Tamoxifen Gel Improves Plaque Psoriasis. An Open Study
April 30, 2018
A Review of Prevalent Methods for Automatic Skin Lesion Diagnosis
January 22, 2018
Possible Spironolactone Induced Intracranial Hypertension in a Patient with Androgenetic Alopecia: A Case Report
December 28, 2017
Prospective Pilot Evaluation of the Efficacy and Safety of Topical Ingenol Mebutate Gel for Localized Patch/Plaque Stage Mycosis Fungoides
November 29, 2017
Sensitizing Capacities and Cross-Reactivity Patterns of Some Diisocyanates and Amines Using the Guinea-Pig Maximization Test. Can p-phenylenediamine be Used as a Marker for Diisocyanate Contact Allergy?
