Aims and Scope
Recent Articles
Clear Cell Acanthoma of the Mammary Region: A Case Report
Piyu Parth Naik
Clear cell acanthoma, also known as Degos acanthoma, is a rare benign epithelial skin tumor. Generally, it appears as a solitary lesion on the lower legs, but in this case, it appeared on the right mammary area near the areola, which is an exceedingly rare and exciting finding. This lesion's clinical features revealed elevated dome-shaped plaque with surface lobulations and shiny pink color with a size of 9 mm. Dermoscopy was characteristic with blood vessels lined up in a strings pattern. Excision biopsy was done as a therapeutic measure. Histopathology showed a collection of glycogen-containing cells in the epidermis consistent with the diagnosis of clear cell acanthoma. Classical dermoscopy features and diagnostic histology were exemplary for a case report.
March 17, 2021
Articles
- February 26, 2021
Disinfectants and Skin Antiseptics for Safe prophylaxis against COVID-19, Review of Literature.
February 16, 2021Topical 5% Imiquimod as Monotherapy for Primary Cutaneous and Cutaneous Metastatic Melanoma: Systematic Review of the Literature
February 23, 2021Serum Vitamin D Levels at Different Stages of Acne Vulgaris Patients Treated with Isotretinoin: A Prospective Study
February 26, 2021
The Impact of Vitiligo on Patients' Psychological Status and Sexual Function: Cross-Sectional Questionnaire-Based Study
Editor's Choice
Fractional Carbon-Dioxide Laser Plus Topical Clotrimazole versus Oral Itraconazole plus Topical Clotrimazole for Onychomycosis: A Randomized, Controlled Trial
Tro V. Chau, Long P. Mai, Hao T. Nguyen, Suong M. Nay, Huyen T.N. Nguyen, Thang T. Nguyen
Background:
Treating onychomycosis is problematic for a variety of reasons. The very nature of the hard, protective nail plate itself makes it difficult for topical drugs to reach the fungal pathogens beneath it. Oral therapy is more effective than topical therapy, but it is expensive, requires monitoring for toxicity, and can result in multiple drug interactions.
Objectives:
To compare the efficacy and safety of fractional CO2 laser combined with topical clotrimazole to oral itraconazole plus topical clotrimazole in the treatment of onychomycosis.
Methods:
A sample of 88 adults (between the ages of 18 and 78) was randomly divided into two groups. 45 patients received fractional CO2 laser therapy at an interval of 2 weeks and twice-daily application of clotrimazole 1% cream. 43 patients were treated by pulsed itraconazole (200 mg twice daily, 1 week on, 3 weeks off) and twice-daily application of clotrimazole 1% cream. The duration of the treatment was 3 months for fingernails and 4 months for toenails in both groups. The clinical effect was measured using the Scoring Clinical Index for Onychomycosis (SCIO index), KOH examination for the affected nails were performed, and liver function tests in the two groups were analyzed.
Results:
73% of patients treated with fractional ablative CO2 laser achieved a negative KOH examination compared with 79% of the itraconazole group (P>0.05). The SCIO reduction in the laser group was superior to that in the itraconazole group (P<0.001). Notably, a biochemical abnormality was not documented in patients who received laser treatment. In contrast, liver transaminases elevations without clinical symptoms were documented in two patients at the end of itraconazole therapy.
Conclusion:
Fractional CO2 laser plus a topical antifungal drug might be more clinically effective in the treatment of onychomycosis than itraconazole, without any adverse reactions. It could be an alternative for clinicians in onychomycosis cases in which oral antifungal agents are contraindicated.
June 30, 2020
Other Post
- April 27, 2020
Ozone Disinfectants Like SoClean CPAP Sanitizer can be used to Sterilize Cloth and n95 Masks in the Protection against COVID-19
April 21, 2020
Current Status of Computational Intelligence Applications in Dermatological Clinical Practice
June 14, 2018
Pyoderma Gangrenosum of the Face: A Rare Presentation and a Rapid Resolution
May 31, 2018
Topical 1% Propranolol in Liposomal Gel: A New Adjuvant Tool for Chronic Leprosy Ulcers
April 30, 2018
0.1MG/ML Tamoxifen Gel Improves Plaque Psoriasis. An Open Study
April 30, 2018
A Review of Prevalent Methods for Automatic Skin Lesion Diagnosis
