Aims and Scope
Serum Vitamin D Levels at Different Stages of Acne Vulgaris Patients Treated with Isotretinoin: A Prospective StudyMohammed Al-Dhubaibi, Ghadah Alhetheli, Adel Alsenaid, Ahmed Abd Elneam
Acne vulgaris is a common chronic inflammatory skin disorder of pilosebaceous units. Isotretinoin (13-cis retinoic acid) is the most effective multifunctional treatment for moderate-to-severe and nodulocystic acne. Vitamin D plays a role in the immune system, and its deficiency might contribute to the pathogenesis of acne.
To investigate whether isotretinoin improves serum 25-hydroxyvitamin D levels in acne vulgaris patients.
This prospective cohort study included 68 patients with acne vulgaris. Lipid profiles, liver function tests, and serum 25-hydroxyvitamin D [25 (OH) D] levels were measured at baseline and three months after starting isotretinoin treatment.
There was a significant increase in serum vitamin D levels three months after starting isotretinoin treatment in mild acne patients (P=0.0003).
Vitamin D levels are altered in acne vulgaris. Isotretinoin therapy is associated with an increase in vitamin D levels, which was statistically significant in mild acne patients. Considering the role of vitamin D in acne, effective treatment with isotretinoin might highlight vitamin D as a possible target for acne therapy or as a biomarker for disease activity and remission.
February 23, 2021
Pyoderma Gangrenosum (PG) is a disorder of neutrophil chemotaxis that often affects the lower extremities of patients with concurrent autoimmune disorders.
Result and Discussion:
Resolution of lesions typically requires a minimum of six weeks of treatment with systemic steroids. We present a unique case of multifocal PG involving the hand and face that healed after ten days of treatment with oral prednisone.
June 14, 2018
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